At 06H38 Thursday morning Netcare 911 responded to reports of a collision on the N3 South bound in Hammersdale Durban West Region.
Reports from the scene indicate that three vehicles were involved in a collision.
Medics assessed the patients and found that one man had sustained fatal injuries and was declared deceased on the scene.
Another patient and adult male was found to have sustained critical injuries and was treated on scene, however his condition rapidly deteriorated and he was declared deceased following a full advanced life support resuscitation.
Seven other patients had sustained minor to serious injuries who were treated on scene and once stabilised were transported by various ambulance services to hospital for further treatment
Circumstances leading up to the collision will be investigated by the relevant authorities.