Netcare 911 responded to reports of a collision on R82 between Roshnee and De Deur.
Reports from the scene indicate that a bakkie and a car were involved in a collision.
Paramedics assessed the scene and found that an adult male and adult female had sustained fatal injuries.
Four adult males from the bakkie sustained moderate injuries.
The patients were treated on scene before being transported by ambulance to hospital for further treatment.